Low blood pressure, particularly orthostatic hypotension (OH), is increasingly recognized as a non-motor complication in Parkinson’s disease (PD). OH, characterized by a drop in blood pressure upon standing, can lead to dizziness, fainting, and falls. This condition is closely tied to autonomic dysfunction, a hallmark of the body-first subtype of Parkinson’s. This literature review explores… Continue reading Understanding Low Blood Pressure in Parkinson’s Disease
Category: Neurological examination
Inflammation and Brain Aging: Gaps and Future Directions
Inflammation plays a critical role in accelerating brain aging and the development of neurodegenerative disorders, including dementia, Parkinson’s disease, and other brain disorders. Despite significant advancements in understanding these inflammatory processes, critical gaps remain, particularly regarding age-dependent responses and their variability across individuals. This literature review synthesizes findings from peer-reviewed research conducted over the past… Continue reading Inflammation and Brain Aging: Gaps and Future Directions
Age-Related Brain Changes
Introduction Understanding how the brain changes with age is crucial for developing interventions to maintain cognitive health in older adults. This literature review examines recent research on age-related brain changes, highlighting current knowledge and identifying areas requiring further investigation. Methodology A comprehensive search was conducted using databases such as PubMed, PsycINFO, and Google Scholar. Keywords… Continue reading Age-Related Brain Changes
GLP-1 Agonists in Neurodegeneration
Introduction Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have transformed the management of type 2 diabetes by helping regulate blood sugar levels and offering protective cardiovascular and renal benefits. Intriguingly, they may also provide significant benefits in neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD), where preliminary studies have shown their potential to modify disease… Continue reading GLP-1 Agonists in Neurodegeneration
Barriers in Parkinson’s Disease
Introduction Parkinson’s disease (PD) is a neurodegenerative disorder that targets dopamine-producing neurons in the brain’s substantia nigra and basal ganglia, leading to a spectrum of motor and nonmotor symptoms. A growing body of research suggests that the blood-brain barrier (BBB) and blood-retinal barrier (BRB) play critical roles in disease progression, as their impairment allows harmful… Continue reading Barriers in Parkinson’s Disease